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Literature summary for 3.6.1.7 extracted from
- Conformational stability of muscle acylphosphatase: the role of temperature, denaturant concentration, and pH (1998), Biochemistry, 37, 1447-1455.
General Stability
| General Stability | Organism |
|---|---|
| highest stability against urea is at pH 9.5 | Homo sapiens |
| muscular enzyme, sensitive to urea: urea denaturation | Homo sapiens |
| no cold denaturation | Homo sapiens |
| studies on conformational stability of muscle acylphosphatase | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| an acylphosphate + H2O = a carboxylate + phosphate | thermodynamic analysis, studies and data | Homo sapiens |
Renatured (Commentary)
| Renatured (Comment) | Organism |
|---|---|
| renaturation after heat denaturation | Homo sapiens |
| renaturation after treatment with urea | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,3-diphosphoglycerate + H2O | - |
Homo sapiens | 3-phosphoglycerate + phosphate | - |
? |  |
| acetyl phosphate + H2O | - |
Homo sapiens | acetate + phosphate | - |
? | |
| acylphosphate + H2O | specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates | Homo sapiens | carboxylate + phosphate | - |
? | |
| carbamoyl phosphate + H2O | - |
Homo sapiens | carbamate + phosphate | - |
? | |
| succinoyl phosphate + H2O | - |
Homo sapiens | succinate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
no cold denaturation | Homo sapiens |
| additional information | - |
increase of urea concentration causes reduction of the thermoresistance of the protein | Homo sapiens |
| additional information | - |
studies on conformational stability of muscle acylphosphatase | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
muscle, pI: 11.4 | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 3.5 | 6.5 | pH range of maximum catalytic activity | Homo sapiens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
studies on conformational stability of muscle acylphosphatase | Homo sapiens |
| 2.5 | 11 | stable between, enzyme is in its native state between, outside this pH range, stability of enzyme collapses abruptly, most probably due to excess of positive or negative charges present at low and high pH | Homo sapiens |
| 3.5 | 6.5 | highest conformational stability between | Homo sapiens |
| 5.5 | - |
maximum stability near pH 5.5 | Homo sapiens |
| 9.5 | - |
highest stability against urea at pH 9.5 | Homo sapiens |
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