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Literature summary for 3.6.1.7 extracted from

  • Nassi, P.; Nediani, C.; Fiorillo, C.; Marchetti, E.; Liguri, G.; Ramponi,G.
    Modifications induced by acylphosphatase in the functional properties of heart sarcolemma Na+,K+ pump (1994), FEBS Lett., 337, 109-113.
    View publication on PubMed
Search for more literature for 3.6.1.7

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000069
-
 Na+/K+-ATPase phosphoenzyme intermediate cardiac muscle, phoshoenzyme intermediate of heart sarcolemma Na+,K+-ATPase Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Bos taurus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-
Bos taurus
-
 two isoenzymatic forms: one prevalent in skeletal and cardiac muscle, the other in red blood cells
-

Purification (Commentary)

Purification (Comment) Organism
heart, cardiac muscle Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
heart cardiac muscle Bos taurus
-
muscle cardiac muscle Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3650
-
 heart, cardiac muscle Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(Ca2+-Mg2+)-ATPase phosphorylated intermediate + H2O acylphosphorylated intermediates of Ca2+-ATPase from skeletal muscle sarcoplasmic reticulum and heart sarcolemma Bos taurus ?
-
 ?
1,3-diphosphoglycerate + H2O
-
 Bos taurus 3-phosphoglycerate + phosphate
-
 ?
acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Bos taurus carboxylate + phosphate
-
 ?
benzoyl phosphate + H2O
-
 Bos taurus benzoate + phosphate
-
 ?
carbamoyl phosphate + H2O
-
 Bos taurus carbamate + phosphate
-
 ?
additional information acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerrated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system Bos taurus ?
-
 ?
Na+/K+-ATPase phosphoenzyme intermediate + H2O sarcolemma Na+,K+-ATPase phosphorylated intermediate Bos taurus ?
-
 ?
Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase significantly enhances the rate of strophantidine-sensitive ATP hydrolysis, it uncouples erythrocyte membrane N+,K+ pump Bos taurus ?
-
 ?
Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase hydrolyzes phosphoenzyme intermediate of heart sarcolemma Na+,K+-ATPase Bos taurus ?
-
 ?
Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphatase increases the rate of Na+,K+-dependent ATP hydrolysis, acylphosphatase significantly stimulates the rate of ATP driven Na+ transport into sarcolemma vesicles: accelerated hydrolysis of the phosphoenzyme may result in an enhanced activity of heart sarcolemma Na+,K+ pump, suggesting a potential role of acylphosphatase in the control of this active transport system Bos taurus ?
-
 ?
Na+/K+-ATPase phosphoenzyme intermediate + H2O acylphosphorylated phosphoenzyme intermediate, enzyme has a high affinity for this substrate Bos taurus ?
-
 ?
succinoyl phosphate + H2O
-
 Bos taurus succinate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
More two isoenzymatic forms: one prevalent in skeletal and cardiac muscle named muscle type, the other in red blood cells named erythrocyte or common type, even if both isoforms are expressed in all tissues Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
100
-
 2 h: heat inactivation Bos taurus