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Literature summary for 3.6.1.7 extracted from

  • Liguri, G.; Nassi, P.; Camici, G.; Manao, G.; Cappugi, G.; Stefani, M.; Berti, A.; Ramponi, G.
    Studies on synthesis and degradation rates and some molecular properties of guinea-pig muscle acylphosphatase (1984), Biochem. J., 217, 499-505.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Cl- competitive inhibition; GP1, Ki: 29.1 mM Cavia porcellus
Cl- competitive inhibition; Ho1, Ki: 40.0 mM Equus caballus
Cl- competitive inhibition; T1, Ki: 40.0 mM Meleagris gallopavo
phosphate competitive inhibition; GP1, Ki: 1.73 mM Cavia porcellus
phosphate competitive inhibition; Ho1, Ki: 1.7 mM Equus caballus
phosphate competitive inhibition; T1, Ki: 2.8 mM Meleagris gallopavo

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetic data Meleagris gallopavo
additional information
-
additional information kinetic data Cavia porcellus
additional information
-
additional information kinetic data Equus caballus
0.57
-
benzoyl phosphate GP1 Cavia porcellus
1
-
benzoyl phosphate T1 Meleagris gallopavo
1.08
-
acetyl phosphate GP1 Cavia porcellus
2
-
benzoyl phosphate Ho1 Equus caballus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Meleagris gallopavo 5737
-
cytoplasm
-
Equus caballus 5737
-
cytoplasm in proximity to sarcoplasmic reticulum Cavia porcellus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
11370
-
muscle, calculated from amino acid sequence Equus caballus
12000
-
GP1, SDS-PAGE Cavia porcellus
12600
-
Ho1, SDS-PAGE Equus caballus
13400
-
T1, SDS-PAGE Meleagris gallopavo
24000
-
GP3, SDS-PAGE Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Meleagris gallopavo acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates ?
-
?
additional information Cavia porcellus acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates ?
-
?
additional information Equus caballus acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates ?
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
guinea pig
-
Cavia porcellus
-
three molecular forms: GP1, GP2 and GP3
-
Equus caballus
-
-
-
Meleagris gallopavo
-
turkey
-

Purification (Commentary)

Purification (Comment) Organism
-
Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
muscle skeletal muscle Meleagris gallopavo
-
muscle skeletal muscle Cavia porcellus
-
muscle skeletal muscle Equus caballus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3300
-
GP2 Cavia porcellus
3500
-
-
Equus caballus
3500
-
GP3 Cavia porcellus
3500
-
T1 Meleagris gallopavo
3600
-
GP1 Cavia porcellus
3800
-
Ho1 Equus caballus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl phosphate + H2O
-
Cavia porcellus acetate + phosphate
-
?
acetyl phosphate + H2O
-
Equus caballus acetate + phosphate
-
?
acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Meleagris gallopavo carboxylate + phosphate
-
?
acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Cavia porcellus carboxylate + phosphate
-
?
acylphosphate + H2O specifically catalyzes the hydrolysis of the carboxyl-phosphate bond of various acylphosphates Equus caballus carboxylate + phosphate
-
?
benzoyl phosphate + H2O
-
Meleagris gallopavo benzoate + phosphate
-
?
benzoyl phosphate + H2O
-
Cavia porcellus benzoate + phosphate
-
?
benzoyl phosphate + H2O
-
Equus caballus benzoate + phosphate
-
?
additional information acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates Meleagris gallopavo ?
-
?
additional information acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates Cavia porcellus ?
-
?
additional information acylphosphatase seems to have a regulatory function, controlling the concentrations of highly reactive compounds such as acyl phosphates Equus caballus ?
-
?

Synonyms

Synonyms Comment Organism
GP 1-3 multiple forms of guinea pig acylphosphatase Cavia porcellus
GP1 multiple forms of guinea pig acylphosphatase, major form Cavia porcellus
GP2 multiple forms of guinea pig acylphosphatase Cavia porcellus
GP3 multiple forms of guinea pig acylphosphatase Cavia porcellus
Ho1 multiple forms of horse acylphosphatase Equus caballus
T1 multiple forms of turkey acylphosphatase Meleagris gallopavo

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Meleagris gallopavo
25
-
assay at Cavia porcellus
25
-
assay at Equus caballus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.1
-
GP1 Cavia porcellus
5.3
-
assay at Meleagris gallopavo
5.3
-
assay at Cavia porcellus
5.3
-
assay at Equus caballus
5.3
-
Ho1 Equus caballus
5.3
-
T1 Meleagris gallopavo