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Literature summary for 3.6.1.62 extracted from

  • Wang, Z.; Jiao, X.; Carr-Schmid, A.; Kiledjian, M.
    The hDcp2 protein is a mammalian mRNA decapping enzyme (2002), Proc. Natl. Acad. Sci. USA, 99, 12663-12668.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.62

Inhibitors

Inhibitors Comment Organism Structure
poly(A) tail presence of a poly(A) tail reduces the level of decapping by more than 2fold. The inhibition of decapping is reversed upon the addition of poly(A) competitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm exclusively in the cytoplasm Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
m7G5'ppp5'-mRNA + H2O Homo sapiens decapping of mRNA is a critical step in eukaryotic mRNA turnover m7GDP + 5'-phospho-mRNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IU60
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
m7G5'ppp5'-mRNA + H2O decapping of mRNA is a critical step in eukaryotic mRNA turnover Homo sapiens m7GDP + 5'-phospho-mRNA
-
 ?
m7G5'ppp5'-mRNA + H2O hDcp2-mediated decapping requires a functional Nudix (nucleotide diphosphate linked to an X moiety) pyrophosphatase motif Homo sapiens m7GDP + 5'-phospho-mRNA
-
 ?

Synonyms

Synonyms Comment Organism
hDcp2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens