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Literature summary for 3.6.1.60 extracted from

  • Safrany, S.T.; Ingram, S.W.; Cartwright, J.L.; Falck, J.R.; McLennan, A.G.; Barnes, L.D.; Shears, S.B.
    The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein (1999), J. Biol. Chem., 274, 21735-21740.
    View publication on PubMed
Search for more literature for 3.6.1.60

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0059
-
 P1,P6-bis(5'-adenosyl)hexaphosphate pH 7.6, 37°C Homo sapiens
0.0077
-
 P1,P5-bis(5'-adenosyl)pentaphosphate pH 7.6, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95989
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme also catalyses the hydrolysis of diphosphoinositol pentakisphosphate Homo sapiens ?
-
 ?
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O the enzyme degrades P1,P6-bis(5'-adenosyl)hexaphosphate and P1,P5-bis(5'-adenosyl)pentaphosphate, in preference to other diadenosine polyphosphates Homo sapiens adenosine 5'-tetraphosphate + AMP
-
 ?
P1,P6-bis(5'-adenosyl)hexaphosphate + H2O the predominant route of P1,P6-bis(5'-adenosyl)hexaphosphate hydrolysis is to AMP plus P1,P5-bis(5'-adenosyl)pentaphosphate, with the formation of ADP plus p4A being a more minor reaction. The enzyme degrades P1,P6-bis(5'-adenosyl)hexaphosphate and P1,P5-bis(5'-adenosyl)pentaphosphate, in preference to other diadenosine polyphosphates Homo sapiens adenosine 5'-pentaphosphate + AMP
-
 ?

Synonyms

Synonyms Comment Organism
DIPP
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.42
-
 P1,P5-bis(5'-adenosyl)pentaphosphate pH 7.6, 37°C Homo sapiens
0.5
-
 P1,P6-bis(5'-adenosyl)hexaphosphate pH 7.6, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
55
-
 P1,P5-bis(5'-adenosyl)pentaphosphate pH 7.6, 37°C Homo sapiens
84.7
-
 P1,P6-bis(5'-adenosyl)hexaphosphate pH 7.6, 37°C Homo sapiens