Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | 0.2 mM, 2fold increase of activity with IDP, 10fold increase of activity with TPP, type L enzyme | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMP | 0.07 mM, , 50% inhibition, type B enzyme | Rattus norvegicus | |
ATP | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
enzyme form B, gel filtration | Rattus norvegicus |
140000 | - |
type L enzyme, gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | enzyme type L and enzyme type B | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CDP + H2O | 43% of the activity with IDP, enzyme type B. 8% of the activity with IDP, enzyme type L | Rattus norvegicus | CMP + phosphate | - |
? | |
dTDP + H2O | 14% of the activity with IDP, type L enzyme | Rattus norvegicus | dTMP + phosphate | - |
? | |
GDP + H2O | 95% of the activity with IDP, enzyme type B and enzyme type L | Rattus norvegicus | GMP + phosphate | - |
? | |
IDP + H2O | - |
Rattus norvegicus | IMP + phosphate | - |
? | |
TPP + H2O | 64% of the activity with IDP, enzyme type B. 4% of the activity with IDP, enzyme type L | Rattus norvegicus | thiamine phosphate + phosphate | - |
? | |
UDP + H2O | 59% of activity with IDP, enzyme type B. 88% of the activity with IDP, enzyme type L | Rattus norvegicus | UMP + phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
hydrolysis of IDP and TPP, enzyme type B | Rattus norvegicus |
6.5 | - |
hydrolysis of IDP, enzyme type L | Rattus norvegicus |
9 | - |
TPPase activity, enzyme type L | Rattus norvegicus |