Application | Comment | Organism |
---|---|---|
medicine | identification of DcpS as a candidate molecular target of the C5-substituted quinazolines for the potential treatment of spinal muscular atrophy | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C5-substituted quinazolines | C5-quinazolines potently inhibit DcpS decapping activity. Binding of C5-substituted quinazolines to DcpS holds the enzyme in an open, catalytically incompetent conformation | Homo sapiens | |
D156844 | highly effective at inhibiting recombinant DcpS decapping activity | Homo sapiens | |
m7G5'ppp5'G | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | DcpS is a nuclear shuttling protein | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
m7G5'ppp5'N(3'ppp5'N)n + H2O | Homo sapiens | n = 1-8 | 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96C86 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
m7G5'ppp5'N(3'ppp5'N)n + H2O | n = 1-8 | Homo sapiens | 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)n | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Dcps | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000015 | - |
pH and temperature not specified in the publication | Homo sapiens | D156844 | |
0.00003 | - |
pH and temperature not specified in the publication | Homo sapiens | m7G5'ppp5'G |