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Literature summary for 3.6.1.58 extracted from

  • Takagi, Y.; Setoyama, D.; Ito, R.; Kamiya, H.; Yamagata, Y.; Sekiguchi, M.
    Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2 (2012), J. Biol. Chem., 287, 21541-21549.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.58

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0107
-
 8-oxo-dGDP in Tris-HCl buffer (pH 8.0), at 37°C Homo sapiens
0.0117
-
 8-oxo-GDP in Tris-HCl buffer (pH 8.0), at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography, HiTrap heparin column chromatography, and Mono S column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-hydroxy-dADP + H2O
-
 Homo sapiens 2-hydroxy-dAMP + phosphate
-
 ?
8-hydroxy-dADP + H2O
-
 Homo sapiens 8-hydroxy-dAMP + phosphate
-
 ?
8-oxo-dGDP + H2O specific substrate Homo sapiens 8-oxo-dGMP + phosphate
-
 ?
8-oxo-dGTP + H2O the enzyme hardly cleaves 8-oxo-dGTP Homo sapiens 8-oxo-dGDP + phosphate
-
 ?
8-oxo-GDP + H2O the enzyme can degrade 8-oxo-GDP as efficiently as 8-oxo-dGDP Homo sapiens 8-oxo-GMP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MTH3
-
 Homo sapiens
MutT homologue 3
-
 Homo sapiens