Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O | Escherichia coli | a step of lipid A biosynthesis. LpxH is essential in Escherichia coli | 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP | - |
? | |
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O | Pseudomonas aeruginosa | step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo | 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O | a step of lipid A biosynthesis. LpxH is essential in Escherichia coli | Escherichia coli | 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP | - |
? | |
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O | step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo | Pseudomonas aeruginosa | 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP | - |
? | |
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O | Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo | Pseudomonas aeruginosa | 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LpxH | - |
Escherichia coli |
LpxH | - |
Pseudomonas aeruginosa |
General Information | Comment | Organism |
---|---|---|
malfunction | construction of Escherichia coli mutant KB21/pKJB5 that contains a kanamycin cassette inserted into the chromosomal copy of lpxH. The plasmid pKJB5 harbors lpxH+ and features a temperature-sensitive origin of replication. KB21/pKJB5 grows on nutrient medium at 30 °C but not at 44 °C when the plasmid carrying lpxH+ is lost. It is conclude that lpxH is essential in Escherichia coli | Escherichia coli |