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Literature summary for 3.6.1.52 extracted from

  • Safrany, S.T.; Ingram, S.W.; Cartwright, J.L.; Falck, J.R.; McLennan, A.G.; Barnes, L.D.; Shears, S.B.
    The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein (1999), J. Biol. Chem., 274, 21735-21740.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information Km-values for hydrolysis of Ap6A and Ap5A Homo sapiens
0.0000042
-
 diphosphoinositol pentakisphosphate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diadenosine 5',5''-P1,P6-hexaphosphate + H2O
-
 Homo sapiens ?
-
 ?
diphosphoinositol pentakisphosphate + H2O
-
 Homo sapiens inositol hexakisphosphate + phosphate
-
 ?
additional information enzyme degrades Ap6A and Ap5A in preference to other diadenosine polyphosphates Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information turnover-numbers for hydrolysis of Ap6A and Ap5A Homo sapiens
0.03
-
 diphosphoinositol pentakisphosphate
-
 Homo sapiens
0.15
-
 diphosphoinositol pentakisphosphate
-
 Homo sapiens
0.2
-
 diphosphoinositol pentakisphosphate
-
 Homo sapiens