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Literature summary for 3.6.1.43 extracted from
- Dolichyl-phosphate phosphatase and dolichyl-diphosphate phosphatase in rat-liver microsomes (1982), Eur. J. Biochem., 125, 167-173.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | optimum activity above 0.14%, stable up to 4.2% | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| divalent cations | - |
Rattus norvegicus | |
| dolichol | - |
Rattus norvegicus | |
| phosphate | slight inhibition | Rattus norvegicus | |
| phosphatidic acid | 70% inhibition at 60 mM | Rattus norvegicus | |
| phosphatidylcholine | nearly full inhibition | Rattus norvegicus | |
| phosphatidylethanolamine | - |
Rattus norvegicus | |
| Triton X-100 | activating | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | inhibited by divalent cations | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dolichyl diphosphate + H2O | Rattus norvegicus | involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate | dolichyl phosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dolichyl diphosphate + H2O | - |
Rattus norvegicus | dolichyl phosphate + phosphate | - |
? | |
| dolichyl diphosphate + H2O | involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate | Rattus norvegicus | dolichyl phosphate + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
- |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.9 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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