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Literature summary for 3.6.1.42 extracted from

  • Vowels, J.J.; Payne, G.S.
    A role for the lumenal domain in Golgi localization of the Saccharomyces cerevisiae guanosine diphosphatase (1998), Mol. Biol. Cell, 9, 1351-1365.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.42

Cloned(Commentary)

Cloned (Comment) Organism
GDA1 gene Saccharomyces cerevisiae

General Stability

General Stability Organism
very stable Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus Golgi localization Saccharomyces cerevisiae 5794
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Golgi apparatus distribution in multiple compartments Saccharomyces cerevisiae 5794
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Golgi lumen large catalytic lumenal domain Saccharomyces cerevisiae 5796
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membrane type II integral membrane glycoprotein with a short amino-terminal cytoplasmic domain, which is not sufficient for Golgi localization, a single transmembrane domain , and a large catalytic lumenal domain, which is required for activity Saccharomyces cerevisiae 16020
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additional information subcellular localization Saccharomyces cerevisiae
-
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additional information Golgi localization Saccharomyces cerevisiae
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
 Saccharomyces cerevisiae
55000
-
 after signal sequence cleavage, metabolic labeling and immunoprecipitation, SDS-PAGE Saccharomyces cerevisiae
57000
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 before signal sequence cleavage, metabolic labeling and immunoprecipitation, SDS-PAGE Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP + H2O Saccharomyces cerevisiae cleaves GDP that originates from GDP-mannose after mannosylation of glycoproteins in Golgi complex 5'-GMP + phosphate
-
 ?
additional information Saccharomyces cerevisiae GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen ?
-
 ?
additional information Saccharomyces cerevisiae necessary for Golgi-specific glycosylation reactions ?
-
 ?
additional information Saccharomyces cerevisiae GDPase has an important role in glycosylation reactions in Golgi lumen ?
-
 ?
additional information Saccharomyces cerevisiae role in mannosylation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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 wild-type and mutants
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein three potential N-glycosylation sites Saccharomyces cerevisiae
glycoprotein N-linked oligosaccharides Saccharomyces cerevisiae
proteolytic modification
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP + H2O
-
 Saccharomyces cerevisiae 5'-GMP + phosphate
-
 ?
GDP + H2O cleaves GDP that originates from GDP-mannose after mannosylation of glycoproteins in Golgi complex Saccharomyces cerevisiae 5'-GMP + phosphate
-
 ?
additional information GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen Saccharomyces cerevisiae ?
-
 ?
additional information necessary for Golgi-specific glycosylation reactions Saccharomyces cerevisiae ?
-
 ?
additional information GDPase has an important role in glycosylation reactions in Golgi lumen Saccharomyces cerevisiae ?
-
 ?
additional information role in mannosylation Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
More
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 Saccharomyces cerevisiae