Cloned (Comment) | Organism |
---|---|
constitutive expression of FHIT in Calu-1 cells, endogenously lacking FHIT protein, FHIT re-expression does not affect cell survival, but a Calu-1 cell clone in which the expression of FHIT is under the control of a CMV promoter, is more resistant to TRAIL-induced, i.e. tumor necrosis factor-related apoptosis inducing ligand-induced, apoptosis than the mock transfected Calu-1 clones | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | FHIT-specific small interference RNA transfection of SV40-immortalized normal bronchial BEAS cells that show levels of FHIT protein comparable to those of normal bronchial cells, results in a significant increase of TRAIL-induced apoptosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
suramin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview | ? | - |
? | |
P1,P3-bis(5'-adenosyl) triphosphate + H2O | Homo sapiens | FHIT protein has been shown to function as a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, forming ADP and AMP from the Ap3A substrate. Tumor suppression by FHIT occurs in lung, gastric, and renal carcinoma-derived cell lines, with Ap3A hydrolysis by FHIT being not necessary for the tumor suppressive activity | ADP + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchial epithelial cell line | a human SV40-immortalized normal bronchial epithelial cell line | Homo sapiens | - |
gastric cancer cell | - |
Homo sapiens | - |
kidney cancer cell | - |
Homo sapiens | - |
lung cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview | Homo sapiens | ? | - |
? | |
P1,P3-bis(5'-adenosyl) triphosphate + H2O | - |
Homo sapiens | ADP + AMP | - |
? | |
P1,P3-bis(5'-adenosyl) triphosphate + H2O | FHIT protein has been shown to function as a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, forming ADP and AMP from the Ap3A substrate. Tumor suppression by FHIT occurs in lung, gastric, and renal carcinoma-derived cell lines, with Ap3A hydrolysis by FHIT being not necessary for the tumor suppressive activity | Homo sapiens | ADP + AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ap3A hydrolase | - |
Homo sapiens |
dinucleoside 5',5'''-P1,P3-triphosphate hydrolase | - |
Homo sapiens |
Fhit | - |
Homo sapiens |
fragile histidine triad | - |
Homo sapiens |