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Literature summary for 3.6.1.29 extracted from

  • Huang, K.; Frey, P.A.
    Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase (2004), J. Am. Chem. Soc., 126, 9548-9549.
    View publication on PubMed
Search for more literature for 3.6.1.29

Protein Variants

Protein Variants Comment Organism
H96G mutant Fhit can not hydrolyse phosphoanhydrides, but can synthetise dinucleoside tri- and tetraphosphates Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
20
-
 UDP pH 7, synthesis of Ap3U by H96G mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for the synthesis of dinucleoside tri- and tetraphosphates by H96G mutant Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyadenosine 5'-phosphoimidazolide + UDP H96G mutant Homo sapiens imidazole + dA(5')p3(5')U
-
 ?
adenosine 5'-phosphoimidazolide + ADP H96G mutant Homo sapiens imidazole + A(5')p3(5')A
-
 ?
adenosine 5'-phosphoimidazolide + ATP H96G mutant Homo sapiens imidazole + A(5')p4(5')A
-
 ?
adenosine 5'-phosphoimidazolide + CDP H96G mutant Homo sapiens imidazole + A(5')p3(5')C
-
 ?
adenosine 5'-phosphoimidazolide + GDP H96G mutant Homo sapiens imidazole + A(5')p3(5')G
-
 ?
adenosine 5'-phosphoimidazolide + TDP H96G mutant Homo sapiens imidazole + A(5')p3(5')T
-
 ?
adenosine 5'-phosphoimidazolide + UDP H96G mutant Homo sapiens imidazole + A(5')p3(5')U
-
 ?
adenosine 5'-phosphoimidazolide + UTP H96G mutant Homo sapiens imidazole + A(5')p4(5')U
-
 ?
cytosine 5'-phosphoimidazolide + UDP H96G mutant Homo sapiens imidazole + C(5')p3(5')U
-
 ?
P1-P3-bis(5'-adenosyl) triphosphate + H2O hydrolysis of Ap3A Homo sapiens ADP + AMP
-
 ?
thymidine 5'-phosphoimidazolide + UDP H96G mutant Homo sapiens imidazole + T(5')p3(5')U
-
 ?

Synonyms

Synonyms Comment Organism
Fhit
-
 Homo sapiens
Fragile histidine triad protein
-
 Homo sapiens