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Literature summary for 3.6.1.27 extracted from

  • Hashizume, H.; Sawa, R.; Harada, S.; Igarashi, M.; Adachi, H.; Nishimura, Y.; Nomoto, A.
    Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate (2011), Antimicrob. Agents Chemother., 55, 3821-3828.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
bacitracin
-
Micrococcus luteus
tripropeptin C tripropeptin C can potentially inhibit C55-PP phosphatase activity, which plays a crucial role in the lipid cycle of peptidoglycan synthesis Micrococcus luteus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Micrococcus luteus 16020
-

Organism

Organism UniProt Comment Textmining
Micrococcus luteus C5CBT8
-
-

Synonyms

Synonyms Comment Organism
C55-PP phosphatase
-
Micrococcus luteus
undecaprenyl pyrophosphate phosphatase
-
Micrococcus luteus
UppP
-
Micrococcus luteus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00003 0.0001 in 100 mM Tris-HCl, 10 mM MgCl2 and 3.9 mM n-dodecyl-beta-maltoside (pH 7.5), 1.25 mM CaCl2, at 30°C Micrococcus luteus tripropeptin C