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Literature summary for 3.6.1.23 extracted from

  • Merenyi, G.; Konya, E.; Vertessy, B.G.
    Drosophila proteins involved in metabolism of uracil-DNA possess different types of nuclear localization signals (2010), FEBS J., 277, 2142-2156.
    View publication on PubMed
Search for more literature for 3.6.1.23

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the short isoform of dUTPase (NTT-DUT) remains exclusively in the cytoplasm Drosophila melanogaster 5737
-
nucleus the long isoform of dUTPase (LD-DUT) is specifically targeted into the nucleus Drosophila melanogaster 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63000
-
 N-terminally truncated short isoform NTT-DUT Drosophila melanogaster
69000
-
 long isoform LD-DUT Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q9V3I1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
homotrimer
-
 Drosophila melanogaster

Synonyms

Synonyms Comment Organism
dUTPase
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction lack of dUTPase leads to uracil-substituted DNA that perturbs base excision repair, resulting in DNA fragmentation and thymine-less cell death Drosophila melanogaster
physiological function dUTPase is responsible for prevention of uracil incorporation into DNA Drosophila melanogaster