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Literature summary for 3.6.1.21 extracted from

  • Moreno-Bruna, B.; Baroja-Fernandez, E.; Munoz, F.J.; Bastarrica-Berasategui, A.; Zandueta-Criado, A.; Rodriguez-Lopez, M.; Lasa, I.; Akazawa, T.; Pozueta-Romero, J.
    Adenosine diphosphate sugar pyrophosphatase prevents glycogen biosynthesis in Escherichia coli (2001), Proc. Natl. Acad. Sci. USA, 98, 8128-8132.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
3-Phosphoglyceric acid
-
 Escherichia coli
ADP
-
 Escherichia coli
AMP
-
 Escherichia coli
ATP
-
 Escherichia coli
diphosphate
-
 Escherichia coli
additional information no substantial inhibition by orthophosphate Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.125
-
 ADP-ribose pH 7.5 Escherichia coli
0.167
-
 ADP-glucose pH 7.5 Escherichia coli
0.183
-
 ADP-mannose pH 7.5 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 2 * 26000, SDS-PAGE Escherichia coli
40000 50000 gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Escherichia coli the enzyme may play a pivotal role in controlling the gluconeogenic process and in interconnecting gluconeogenesis with other metabolic pathways ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
9.511
-
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-glucose + H2O
-
 Escherichia coli AMP + alpha-D-glucose 1-phosphate
-
 ?
ADP-mannose + H2O
-
 Escherichia coli AMP + alpha-D-mannose 1-phosphate
-
 ?
ADP-ribose + H2O
-
 Escherichia coli AMP + alpha-D-ribose 1-phosphate
-
 ?
additional information the enzyme may play a pivotal role in controlling the gluconeogenic process and in interconnecting gluconeogenesis with other metabolic pathways Escherichia coli ?
-
 ?
additional information no activity with UDPglucose, CDPglucose, GDPmannose, adenosine 5'-phosphosulfate, diphosphate, synthetic phosphodiester bonds containing compounds such as p-nitrophenylphosphate, sugar phosphates and nucleoside mono-, di- and triphosphates Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 26000, SDS-PAGE Escherichia coli

Synonyms

Synonyms Comment Organism
adenosine diphosphate sugar pyrophosphatase
-
 Escherichia coli
ASPPase
-
 Escherichia coli