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Literature summary for 3.6.1.18 extracted from

  • Kim, J.K.; Ezaki, J.; Himeno, M.; Kato, K.
    Purification and characterization of flavine-adenine dinucleotide phosphohydrolase from rat liver lysosomal membranes (1993), J. Biochem., 114, 126-131.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
Rattus norvegicus
dithiothreitol
-
Rattus norvegicus
EDTA strong inhibition Rattus norvegicus
N-ethylmaleimide
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
FAD
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome membrane Rattus norvegicus 5764
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ no effect Rattus norvegicus
Zn2+ slight stimulation Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
SDS-PAGE Rattus norvegicus
560000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
FAD + H2O Rattus norvegicus
-
FMN + AMP
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
539
-
membrane fraction Rattus norvegicus
250000
-
purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CoA + H2O
-
Rattus norvegicus ?
-
?
FAD + H2O
-
Rattus norvegicus FMN + AMP
-
?
NADH + H2O
-
Rattus norvegicus NMNH + AMP
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 140000, SDS-PAGE, gel filtration Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 10 20% of maximum activity at both pH Rattus norvegicus