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Literature summary for 3.6.1.17 extracted from

  • Pinto, R.M.; Costas, M.J.; Fernandez, A.; Canales, J.; Garcia-Agundez, J.A.; Camselle, J.C.
    Dinucleoside tetraphosphatase from human blood cells: Purification and characterization as a high specific activity enzyme recognized by an anti-rat tetraphosphatase antibody (1991), FEBS Lett., 287, 85-88.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-tetraphosphate competitive; Ki in nanomolar range Homo sapiens
adenosine 5'-tetraphosphate Ki in nanomolar range Rattus norvegicus
fluoride
-
Homo sapiens
fluoride
-
Rattus norvegicus
Zn2+
-
Homo sapiens
Zn2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007
-
P1,P4-bis(5'-adenosyl) tetraphosphate
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required, optimum concentration 3-10 mM Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
SDS-PAGE, immunoblot Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Homo sapiens
-
ATP + AMP
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O Rattus norvegicus
-
ATP + AMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0001
-
crude extract Homo sapiens
18.5
-
purified enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
Homo sapiens ATP + AMP
-
?
P1,P4-bis(5'-adenosyl) tetraphosphate + H2O
-
Rattus norvegicus ATP + AMP
-
?