Literature summary for 3.6.1.12 extracted from

Zhang, Y.; Ye, W.Y.; Wang, J.Q.; Wang, S.J.; Ji, P.; Zhou, G.Y.; Zhao, G.P.; Ge, H.L.; Wang, Y.
dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas (2013), Eur. J. Histochem., 57, e29.

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Application

Application	Comment	Organism
medicine	enzyme accumulates in the nucleus of cancer cells compared to the paired adjacent tissue cells in multiple carcinomas including lung, breast, liver, cervical, gastric and esophagus cancer. The higher expression in the nucleus of lung, gastric and esophagus cancer cells is associated with histological subtypes. The nucleic accumulation is apparently observed as well when tumor cell line MCF-7 is treated with H2O2 in vitro	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	enzyme accumulates in the nucleus of tumor cells	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H773	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)