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Literature summary for 3.6.1.12 extracted from

  • Zimmerman, S.B.; Kornberg, A.
    Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli (1961), J. Biol. Chem., 236, 1480-1486.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dCDP competitive inhibition of hydrolysis of dCTP Escherichia phage T2
dCMP competitive inhibition of hydrolysis of dCTP and dCDP Escherichia phage T2
dCTP competitive inhibition of hydrolysis of dCDP Escherichia phage T2
F-
-
Escherichia phage T2

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia phage T2

Organism

Organism UniProt Comment Textmining
Escherichia phage T2
-
Escherichia coli infected with bacteriophage T2r+, activity found in uninfected cells is 0.1% or less of that found in uninfected cells
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia phage T2

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Escherichia phage T2

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCDP + H2O
-
Escherichia phage T2 ?
-
?
dCTP + H2O
-
Escherichia phage T2 dCMP + diphosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Escherichia phage T2

pH Range

pH Minimum pH Maximum Comment Organism
8 10 pH 8.0: about 55% of maximal activity, pH 10.0: about 35% of maximal activity Escherichia phage T2