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Literature summary for 3.6.1.1 extracted from
- PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans (2007), FEBS Lett., 581, 5445-5453.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene pyp-1, DNA and amino acid sequence determination and analysis, genomic organization, expression in transformed adult progeny worms using the promoterless GFP vector, pPD95.75 vector | Caenorhabditis elegans |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | isolation of pyp-1 deletion mutant, a constructed null mutant of pyp-1 reveals a developmental arrest at early larval stages and exhibits gross defects in intestinal morphology and function, phenotype, overview | Caenorhabditis elegans |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Caenorhabditis elegans | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | Caenorhabditis elegans | diphosphate hydrolysis provides a thermodynamic driving force for important biosynthetic reactions, PYP-1 is required for larval development and intestinal function, overview | 2 phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q18680 | Bristol strain N2, gene C47E12.4 or pyp-1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| coelomocyte | - |
Caenorhabditis elegans | - |
| intestine | PYP-1 is required for larval development and intestinal function, overview | Caenorhabditis elegans | - |
| larva | PYP-1 is required for larval development and intestinal function, overview | Caenorhabditis elegans | - |
| additional information | expression can be detected from larval stages through adult stages | Caenorhabditis elegans | - |
| nervous system | nerve cords and sensory neurons | Caenorhabditis elegans | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1570 | - |
recombinant enzyme | Caenorhabditis elegans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | - |
Caenorhabditis elegans | 2 phosphate | - |
? | |
| diphosphate + H2O | diphosphate hydrolysis provides a thermodynamic driving force for important biosynthetic reactions, PYP-1 is required for larval development and intestinal function, overview | Caenorhabditis elegans | 2 phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inorganic pyrophosphatase | - |
Caenorhabditis elegans |
| PPase | - |
Caenorhabditis elegans |
| PYP-1 | - |
Caenorhabditis elegans |
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