Literature summary for 3.5.99.7 extracted from

Karthikeyan, S.; Zhou, Q.; Zhao, Z.; Kao, C.L.; Tao, Z.; Robinson, H.; Liu, H.W.; Zhang, H.
Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5-phosphate dependent cyclopropane ring-opening reaction (2004), Biochemistry, 43, 13328-13339.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with substrate 1-aminocyclopropane-1-carboxylate, inhibitor 1-aminocyclopropane-1-phosphonate, product alpha-ketobutanoate, and two D-amino acids	Pseudomonas sp.

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas sp.	Q00740	-	-
Pseudomonas sp. ACP	Q00740	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3	ring cleavage is induced by a nucleophilic attack at the pro-S-beta-methylene carbon of substrate, with Tyr294 as the nucleophile. Alternatively, ring opening is acid-catalyzed and may be facilitated by charge relay through pyridoxal 5-phosphate, with Tyr294 as general acid	Pseudomonas sp.	a

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Release 2023.1 (January 2023)