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Literature summary for 3.5.99.6 extracted from

  • Pattabiraman, T.N.; Bachhawat, B.K.
    Purification of glucosamine 6-phosphate deaminase from human brain (1961), Biochim. Biophys. Acta, 54, 273-283.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
PCMB inhibits at high concentrations, activates at low concentrations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cd2+
-
Homo sapiens
cysteine
-
Homo sapiens
diphosphate
-
Homo sapiens
EDTA
-
Homo sapiens
PCMB inhibits at high concentrations, activates at low concentrations Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
D-glucosamine 6-phosphate pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ Homo sapiens
2.37
-
D-glucosamine 6-phosphate pH 8.5, 37°C, without activator Homo sapiens
3.5
-
D-fructose 6-phosphate pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ Homo sapiens
16
-
NH4+ pH 8.5, 37°C, in presence of N-acetylglucosamine 6-phosphate and Mn2+ Homo sapiens
22.5
-
D-fructose 6-phosphate pH 8.5, 37°C, in absence of activators Homo sapiens
25
-
NH4+ in absence of activators Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activates Homo sapiens
Hg2+ activates Homo sapiens
Mg2+ activates Homo sapiens
Mn2+ activates, reverses inhibition by EDTA Homo sapiens
additional information Mn2+, Hg2+, Mg2+, Co2+ and Ni2+ enhance in decreasing order the activity in both directions Homo sapiens
Ni2+ activates Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucosamine 6-phosphate + H2O
-
Homo sapiens D-fructose 6-phosphate + NH3
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 8.7
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 pH 7.0: about 55% of maximal activity, pH 9.5: about 74% of maximal activity Homo sapiens