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Literature summary for 3.5.4.B9 extracted from

  • Coker, H.A.; Petersen-Mahrt, S.K.
    The nuclear DNA deaminase AID functions distributively whereas cytoplasmic APOBEC3G has a processive mode of action (2006), DNA Repair, 6, 235-243.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded viral DNA + H2O Homo sapiens in vitro, the enzyme has a preferred sequence motif of T/CCC and shows a 3'->5' like processivity uracil in single-stranded viral DNA + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC16
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded viral DNA + H2O in vitro, the enzyme has a preferred sequence motif of T/CCC and shows a 3'->5' like processivity Homo sapiens uracil in single-stranded viral DNA + NH3
-
?

Synonyms

Synonyms Comment Organism
APOBEC3G
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme inhibits HIV replication and inhibits retroviral infection by deaminating first strand cDNA, generating viral DNA mutations and potential viral elimination Homo sapiens