Protein Variants | Comment | Organism |
---|---|---|
F126A/W127A | the mutant interferes with head-to-head dimerization but retains many of the salient biochemical properties observed in the native protein | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | contains zinc | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | Homo sapiens | - |
uracil in single-stranded viral DNA + NH3 | - |
? | |
additional information | Homo sapiens | the enzyme deaminates C -> U on single-stranded DNA, but favors 5'CCCC target motifs with a preference for the 3'C, and its specific activity is strongly influenced by nucleotides surrounding the 5'CCC target motif | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HC16 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
additional information | the enzyme deaminates C -> U on single-stranded DNA, but favors 5'CCCC target motifs with a preference for the 3'C, and its specific activity is strongly influenced by nucleotides surrounding the 5'CCC target motif | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme is a mix of monomers, dimers, and higher order oligomers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Apo3G | - |
Homo sapiens |
Apobec 3G | - |
Homo sapiens |
APOBEC3G | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer | Homo sapiens |