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Literature summary for 3.5.4.B9 extracted from

  • Jaszczur, M.; Bertram, J.G.; Pham, P.; Scharff, M.D.; Goodman, M.F.
    AID and Apobec3G haphazard deamination and mutational diversity (2013), Cell. Mol. Life Sci., 70, 3089-3108.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F126A/W127A the mutant interferes with head-to-head dimerization but retains many of the salient biochemical properties observed in the native protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded viral DNA + H2O Homo sapiens
-
uracil in single-stranded viral DNA + NH3
-
?
additional information Homo sapiens the enzyme deaminates C -> U on single-stranded DNA, but favors 5'CCCC target motifs with a preference for the 3'C, and its specific activity is strongly influenced by nucleotides surrounding the 5'CCC target motif ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC16
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded viral DNA + H2O
-
Homo sapiens uracil in single-stranded viral DNA + NH3
-
?
additional information the enzyme deaminates C -> U on single-stranded DNA, but favors 5'CCCC target motifs with a preference for the 3'C, and its specific activity is strongly influenced by nucleotides surrounding the 5'CCC target motif Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More the enzyme is a mix of monomers, dimers, and higher order oligomers Homo sapiens

Synonyms

Synonyms Comment Organism
Apo3G
-
Homo sapiens
Apobec 3G
-
Homo sapiens
APOBEC3G
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer Homo sapiens