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Literature summary for 3.5.4.B9 extracted from

  • Li, X.; Ma, J.; Zhang, Q.; Zhou, J.; Yin, X.; Zhai, C.; You, X.; Yu, L.; Guo, F.; Zhao, L.; Li, Z.; Zeng, Y.; Cen, S.
    Functional analysis of the two cytidine deaminase domains in APOBEC3G (2011), Virology, 414, 130-136.
    View publication on PubMed
Search for more literature for 3.5.4.B9

Cloned(Commentary)

Cloned (Comment) Organism
incorporation of hA3G CD1 and CD2 domain mutants into HIV-1. Cotransfection of plasmids coding HIV-1 vif and plasmids containing either wild-type or mutant hA3G in 293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information CD2-2, possessing the deamination activity, incorporated efficiently into HIV-1 is unable to mutate viral cDNA. Construction of three A3G mutants CD1-1, CD2-2 and CD2-1, which contain duplicate CD1 domain, duplicate CD2 domain, and position switched CD domain, respectively. The two CD domains are functionally equivalent in virion encapsidation and the interaction with HIV-1 Vif of hA3G, whereas CD domain switch or replacement greatly affect the sensitivity to Vif-induced degradation, editing and antiviral activity of hA3G. The switch of the CD domain affects nucleotide sequence preference pattern of the deaminase. The mutants show a nucleotide sequence preference pattern Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the preferred sequence context for wild-type hA3G is GG. In the CD2-1 mutant variants, both TGG and GGG are preferred, while the wild-type prefers TGG Homo sapiens ?
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 ?

Subunits

Subunits Comment Organism
More A3G contains two cytidine deaminase domains. The CD2 domain possesses the deamination activity Homo sapiens

Synonyms

Synonyms Comment Organism
A3G
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 Homo sapiens
APOBEC3G
-
 Homo sapiens