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Literature summary for 3.5.4.9 extracted from

  • Shin, M.; Momb, J.; Appling, D.R.
    Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (2017), Cancer Metab., 5, 11 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.9

Cloned(Commentary)

Cloned (Comment) Organism
6His-tagged enzyme is expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
36700
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P13995
-
-
Homo sapiens Q9H903
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell highly expressed in many cancer types Homo sapiens
-
embryo both Mthfd2 and Mthfd2l are expressed during embryogenesis but differ in timing of expression. Mthfd2l expression is low in early developmental stages but begins to increase at embryonic day 10.5 and remains elevated through birth while Mthfd2 is expressed more abundantly during early developmental stages and begins to taper off, with little or no expression observed in most adult tissues Homo sapiens
-

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase
-
 Homo sapiens
MTHFD2
-
 Homo sapiens
MTHFD2L
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in folate pathway. It is involved in mitochondrial NADPH production Homo sapiens