Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.9 extracted from

  • Jaffe, J.J.; Chrin, L.R.; Smith, R.B.
    5,10-Methenyltetrahydrofolate cyclohydrolase and 5-formyltetrahydrofolate cyclodehydrase in Aedes aegypti (1980), Comp. Biochem. Physiol. B, 66, 597-600.
No PubMed abstract available
Search for more literature for 3.5.4.9

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Aedes aegypti
Cu2+
-
 Bos taurus
Fe2+
-
 Aedes aegypti
Fe2+
-
 Bos taurus
Mg2+
-
 Aedes aegypti
Mg2+
-
 Bos taurus
p-chloromercuribenzoate
-
 Aedes aegypti
suramin
-
 Aedes aegypti
Zn2+
-
 Aedes aegypti
Zn2+
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.07
-
 10-formyltetrahydrofolate
-
 Sus scrofa
0.07
-
 10-formyltetrahydrofolate
-
 Aedes aegypti
0.09
-
 5,10-methenyltetrahydrofolate
-
 Aedes aegypti
0.1
-
 10-formyltetrahydrofolate
-
 Bos taurus
0.25
-
 5,10-methenyltetrahydrofolate
-
 Bos taurus
0.25
-
 5,10-methenyltetrahydrofolate
-
 Ovis aries
0.47
-
 10-formyltetrahydrofolate
-
 Ovis aries

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
 gel filtration Aedes aegypti
218000
-
 isoenzyme Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
10-formyltetrahydrofolate Sus scrofa
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate Bos taurus
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate Oryctolagus cuniculus
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate Aedes aegypti
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate Aedes aegypti black-eye
-
 5,10-methenyltetrahydrofolate + H2O
-
 r
5,10-methenyltetrahydrofolate + H2O Sus scrofa
-
 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O Bos taurus
-
 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O Oryctolagus cuniculus
-
 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O Ovis aries
-
 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O Aedes aegypti
-
 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O Aedes aegypti black-eye
-
 10-formyltetrahydrofolate
-
 r

Organism

Organism UniProt Comment Textmining
Aedes aegypti
-
 mosquito, Liverpool black-eye strain
-
Aedes aegypti black-eye
-
 mosquito, Liverpool black-eye strain
-
Bos taurus
-
 beef
-
Oryctolagus cuniculus
-
 rabbit
-
Ovis aries
-
 sheep, trifunctional enzyme
-
Sus scrofa
-
 pig, trifunctional enzyme
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Sus scrofa
-
liver
-
 Bos taurus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
10-formyltetrahydrofolate
-
 Sus scrofa 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate
-
 Bos taurus 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate
-
 Oryctolagus cuniculus 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate
-
 Aedes aegypti 5,10-methenyltetrahydrofolate + H2O
-
 r
10-formyltetrahydrofolate
-
 Aedes aegypti black-eye 5,10-methenyltetrahydrofolate + H2O
-
 r
5,10-methenyltetrahydrofolate + H2O
-
 Sus scrofa 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O
-
 Bos taurus 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O
-
 Oryctolagus cuniculus 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O
-
 Ovis aries 10-formyltetrahydrofolate
-
 ?
5,10-methenyltetrahydrofolate + H2O
-
 Aedes aegypti 10-formyltetrahydrofolate
-
 r
5,10-methenyltetrahydrofolate + H2O
-
 Aedes aegypti black-eye 10-formyltetrahydrofolate
-
 r

Synonyms

Synonyms Comment Organism
CHF4CH
-
 Aedes aegypti
mosquito cyclohydrolase
-
 Aedes aegypti

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Aedes aegypti