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Literature summary for 3.5.4.6 extracted from

  • Borkowski, T.; Orlewska, C.; Slominska, E.M.; Yuen, A.; Lipinski, M.; Rybakowska, I.; Foks, H.; Kaletha, K.K.; Yacoub, M.H.; Smolenski, R.T.
    Pharmacological inhibition of AMP-deaminase in rat cardiac myocytes (2008), Nucleosides Nucleotides Nucleic Acids, 27, 867-871.
    View publication on PubMed
Search for more literature for 3.5.4.6

Inhibitors

Inhibitors Comment Organism Structure
3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol specific inhibitor Homo sapiens
3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol specific inhibitor Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
phosphocellulose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Rattus norvegicus
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AMP + H2O
-
 Homo sapiens IMP + NH3
-
 ?
AMP + H2O
-
 Rattus norvegicus IMP + NH3
-
 ?

Synonyms

Synonyms Comment Organism
AMP-deaminase
-
 Homo sapiens
AMP-deaminase
-
 Rattus norvegicus
AmpD
-
 Homo sapiens
AmpD
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.5
-
-
 Rattus norvegicus 3-[2-(3-carboxy-4-bromo-5,6,7,8-tetrahydronaphthyl)ethyl]-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol