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Literature summary for 3.5.4.5 extracted from
- Optimized blood sampling with cytidine deaminase inhibitor for improved analysis of capecitabine metabolites (2008), J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 870, 117-120.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| tetrahydrouridine | THU, the presence of 1 microM totally prevents the formation of 5'-deoxy-5-fluorouridine in blood samples of healthy volunteers and capecitabine-treated patients | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-deoxyfluorocytidine + H2O | - |
Homo sapiens | 5'-deoxy-5-fluorouridine + NH3 | - |
? | |
| cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDA | - |
Homo sapiens |
| cytidine deaminase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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