Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(cytidyl)acryloylaminohexanoic acid | i.e. CV6 | Homo sapiens | |
3,4,5,6-Tetrahydrouridine | - |
Homo sapiens | |
5,6-Dihydrouridine | - |
Homo sapiens | |
5-fluorozebularine | - |
Homo sapiens | |
cytidine monophosphate | - |
Homo sapiens | |
uridine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
2'-deoxycytidine | native enzyme, 37°C | Homo sapiens | |
0.04 | - |
cytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.04 | - |
2'-deoxycytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.042 | - |
2'-deoxycytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.042 | - |
cytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.087 | - |
5-iododeoxycytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.1 | - |
5-iododeoxycytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.11 | - |
cytosine arabinoside | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.15 | - |
cytosine arabinoside | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.28 | - |
5-azacytidine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.31 | - |
5-azacytidine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
15000 | - |
4 * 15000, SDS-PAGE | Homo sapiens |
60000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | different arrangement of subunit isoforms CDA1 and CDA2 results in five isoforms differing only in isoelectric point, native and recombinant enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-deoxycytidine + H2O | - |
Homo sapiens | 2'-deoxyuridine + NH3 | - |
? | |
5-azacytidine + H2O | - |
Homo sapiens | 5-azauridine + NH3 | - |
? | |
5-iododeoxycytidine + H2O | - |
Homo sapiens | 5-iododeoxyuridine + NH3 | - |
? | |
cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Homo sapiens | uridine arabinoside + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | 4 * 15000, SDS-PAGE | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00006 | - |
5-fluorozebularine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.0003 | - |
5-fluorozebularine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.007 | - |
3,4,5,6-Tetrahydrouridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.007 | - |
3,4,5,6-Tetrahydrouridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.015 | - |
5,6-Dihydrouridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.034 | - |
(cytidyl)acryloylaminohexanoic acid | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.04 | - |
5,6-Dihydrouridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.045 | - |
(cytidyl)acryloylaminohexanoic acid | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.3 | - |
cytidine monophosphate | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.31 | - |
uridine | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens | |
0.31 | - |
uridine | tetramer of recombinant subunit CDA2, 37°C | Homo sapiens | |
0.39 | - |
cytidine monophosphate | tetramer of recombinant subunit CDA1, 37°C | Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | tetramer of recombinant subunit CDA2, isoelectric focusing | - |
4.5 |
Homo sapiens | 5 different isoforms of native enzyme, isoelectric focusing | 4.9 | 4.55 |
Homo sapiens | tetramer of recombinant subunit CDA1, isoelectric focusing | - |
5 |