Application | Comment | Organism |
---|---|---|
medicine | enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,4,5,6-Tetrahydrouridine | - |
Homo sapiens | |
diazepinone riboside | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0463 | - |
deoxycytidine | - |
Homo sapiens | |
0.0957 | - |
2',2'-difluorodeoxycytidine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.011 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',2'-difluorodeoxycytidine + H2O | gemcitabine, antimetabolite of deoxycytidine, active against solid tumors and leukemic cell lines, deamination by the enzyme results in loss of pharmacologic activity | Homo sapiens | 2',2'-difluorodeoxyuridine + NH3 | - |
? | |
cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CDA | - |
Homo sapiens |