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Literature summary for 3.5.4.5 extracted from

  • Barchi, J.J.; Haces, A.; Marquez, V.E.; McCormack, J.J.
    Inhibition of cytidine deaminase by derivatives of 1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one(zebularine) (1992), Nucleosides Nucleotides, 11, 1781-1793.
No PubMed abstract available

Application

Application Comment Organism
medicine enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one zebularine Homo sapiens
2'-deoxyzebularine 5'-monophosphate
-
Homo sapiens
3,4,5,6-Tetrahydrouridine
-
Homo sapiens
3,4,5,6-Tetrahydrouridine
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.05
-
cytidine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytidine + H2O Mus musculus
-
uridine + NH3
-
?
cytidine + H2O Homo sapiens
-
uridine + NH3
-
?
cytidine + H2O Mus musculus BALB/c
-
uridine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Mus musculus
-
BALB/c
-
Mus musculus BALB/c
-
BALB/c
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
spleen
-
Mus musculus
-
spleen
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytidine + H2O
-
Mus musculus uridine + NH3
-
?
cytidine + H2O
-
Homo sapiens uridine + NH3
-
?
cytidine + H2O
-
Mus musculus BALB/c uridine + NH3
-
?

Synonyms

Synonyms Comment Organism
CDA
-
Homo sapiens