Application | Comment | Organism |
---|---|---|
medicine | enzyme limits the effectiveness of the antineoplastic agent cytosine arabinoside or aracytidine in the treatment of acute myeloblastic leukemias, chemotherapeutic use of the inhibitor THU to protect antileukemic agents from deaminase attack, inhibitors of cytidine deaminase prolongs the plasma halflife of antitumor or antiviral drugs | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxyuridine | - |
Homo sapiens | |
2-thio-6-azarudine | - |
Homo sapiens | |
3'-azido-3'-deoxythymidine | - |
Homo sapiens | |
3-deazauridine | - |
Homo sapiens | |
4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one | - |
Homo sapiens | |
4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one | - |
Homo sapiens | |
4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one | - |
Homo sapiens | |
5,6-Dihydrouridine | - |
Escherichia coli | |
5,6-Dihydrouridine | - |
Homo sapiens | |
5-(Chloromercuri)cytidine | - |
Escherichia coli | |
5-(Chloromercuri)cytidine | - |
Homo sapiens | |
5-Bromouridine | - |
Homo sapiens | |
5-fluoro-2'-deoxyuridine | - |
Homo sapiens | |
5-fluorouridine | - |
Homo sapiens | |
5-iodo-2'-deoxyuridine | - |
Homo sapiens | |
5-methyluridine | - |
Homo sapiens | |
5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine | - |
Homo sapiens | |
6-azauridine | - |
Homo sapiens | |
Ag+ | - |
Homo sapiens | |
ara-U | - |
Homo sapiens | |
CMP | - |
Homo sapiens | |
Cu2+ | - |
Escherichia coli | |
Cu2+ | - |
Homo sapiens | |
Cu2+ | - |
Mus musculus | |
dCMP | - |
Homo sapiens | |
deoxyadenosine | - |
Escherichia coli | |
deoxyadenosine | - |
Homo sapiens | |
DTNB | - |
Homo sapiens | |
DTNB | - |
Mus musculus | |
dTTP | - |
Homo sapiens | |
dTTP | - |
Mus musculus | |
Hg+ | - |
Escherichia coli | |
Hg+ | - |
Homo sapiens | |
Hg+ | - |
Mus musculus | |
N-ethylmaleimide | weak inhibition | Homo sapiens | |
N-ethylmaleimide | - |
Mus musculus | |
p-chloromercuribenzoate | - |
Homo sapiens | |
pseudouridine | - |
Homo sapiens | |
thymidine | - |
Escherichia coli | |
thymidine | - |
Homo sapiens | |
thymine riboside | - |
Escherichia coli | |
thymine riboside | - |
Homo sapiens | |
uridine | - |
Escherichia coli | |
uridine | - |
Homo sapiens | |
UTP | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
13500 | - |
4 * 13500, SDS-PAGE | Homo sapiens |
52000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytidine + H2O | Gallus gallus | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Mus musculus | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Escherichia coli | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Homo sapiens | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Canis lupus familiaris | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Mus musculus BALB/c | - |
uridine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Escherichia coli | - |
- |
- |
Gallus gallus | - |
chicken | - |
Homo sapiens | - |
human | - |
Mus musculus | - |
mouse | - |
Mus musculus | - |
BALB/c | - |
Mus musculus BALB/c | - |
BALB/c | - |
no activity in Lactobacillus sp. | - |
- |
- |
no activity in Moraxella sp. | - |
Neisseria meningitidis | - |
no activity in Pseudomonas sp. | - |
P. acidovorans | - |
Purification (Comment) | Organism |
---|---|
- |
Gallus gallus |
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulocyte | normal and leukemic | Homo sapiens | - |
liver | - |
Gallus gallus | - |
liver | - |
Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | - |
Canis lupus familiaris | - |
lymphocyte | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
reticulocyte | - |
Homo sapiens | - |
spleen | - |
Mus musculus | - |
spleen | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
64.1 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 20% glycerol appears to be necessary to prevent inactivation from occuring after freezing and thawing | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O | - |
Homo sapiens | ? | - |
? | |
1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine + H2O | - |
Canis lupus familiaris | ? | - |
? | |
1-beta-D-arabinofuranosylcytosine + H2O | - |
Mus musculus | ? | - |
? | |
1-beta-D-arabinofuranosylcytosine + H2O | - |
Escherichia coli | ? | - |
? | |
1-beta-D-arabinofuranosylcytosine + H2O | - |
Homo sapiens | ? | - |
? | |
1-beta-D-arabinofuranosylcytosine + H2O | - |
Canis lupus familiaris | ? | - |
? | |
2'-deoxycytidine + H2O | - |
Mus musculus | 2'-deoxyuridine + NH3 | - |
? | |
2'-deoxycytidine + H2O | - |
Escherichia coli | 2'-deoxyuridine + NH3 | - |
? | |
2'-deoxycytidine + H2O | - |
Homo sapiens | 2'-deoxyuridine + NH3 | - |
? | |
2'-deoxycytidine + H2O | - |
Mus musculus BALB/c | 2'-deoxyuridine + NH3 | - |
? | |
2'-fluoro-2'-deoxycytidine + H2O | - |
Escherichia coli | 2'-fluoro-2'-deoxyuridine + NH3 | - |
? | |
2'-fluoro-2'-deoxycytidine + H2O | - |
Homo sapiens | 2'-fluoro-2'-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Mus musculus | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Escherichia coli | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Homo sapiens | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Mus musculus BALB/c | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5-azacytidine + H2O | - |
Escherichia coli | 5-azauridine + NH3 | - |
? | |
5-azacytidine + H2O | - |
Homo sapiens | 5-azauridine + NH3 | - |
? | |
5-azadeoxycytidine + H2O | - |
Homo sapiens | 5-azadeoxyuridine + NH3 | - |
? | |
5-iodo-2'-deoxycytidine | - |
Homo sapiens | 5-iodo-2'-deoxyuridine + NH3 | - |
? | |
5-iododeoxycytidine + H2O | - |
Mus musculus | 5-iododeoxyuridine + NH3 | - |
? | |
5-iododeoxycytidine + H2O | - |
Homo sapiens | 5-iododeoxyuridine + NH3 | - |
? | |
5-methylcytidine + H2O | - |
Escherichia coli | 5-methyluridine + NH3 | - |
? | |
5-methylcytidine + H2O | - |
Homo sapiens | 5-methyluridine + NH3 | - |
? | |
cytidine + H2O | - |
Gallus gallus | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Mus musculus | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Escherichia coli | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Homo sapiens | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Canis lupus familiaris | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Mus musculus BALB/c | uridine + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Mus musculus | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Escherichia coli | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Homo sapiens | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Mus musculus BALB/c | uridine arabinoside + NH3 | - |
? | |
deoxycytidine + H2O | - |
Mus musculus | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Escherichia coli | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Homo sapiens | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Canis lupus familiaris | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Mus musculus BALB/c | deoxyuridine + NH3 | - |
? | |
additional information | - |
Escherichia coli | ? | - |
? | |
additional information | 3-methylcytidine, cytosine and cyclocytidine are no substrates | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Gallus gallus |
tetramer | 4 * 13500, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
cytidine/2'-deoxycytidine aminohydrolase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.5 | 10.5 | deoxycytidine as substrate, beyond these values irreversible inactivation occurs | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
3.5 | 10.5 | deoxycytidine as substrate, beyond these extremes rapid inactivation | Homo sapiens |