Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | - |
Mus musculus | |
EDTA | 10 mM, activity 108% | Escherichia coli | |
iodoacetic acid | 0.10 mM, activity 105% | Escherichia coli | |
N-ethylmaleimide | 0.10-0.20 mM, activity 114% | Escherichia coli | |
p-chloromercuribenzoate | 0.105 mM, activity 112% | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-bromodeoxyuridine | 1.0 mM, 31% inhibition | Escherichia coli | |
adenosine | 4.0 mM, 22% inhibition | Escherichia coli | |
Cu2+ | - |
Escherichia coli | |
Cu2+ | - |
Mus musculus | |
deoxyadenosine | 3.0 mM, 32% inhibition | Escherichia coli | |
deoxyguanosine | 1.0 mM, 13% inhibition | Escherichia coli | |
deoxyuridine | 1.0 mM, 32% inhibition | Escherichia coli | |
dTTP | - |
Mus musculus | |
dTTP | - |
Ovis aries | |
dTTP | 0.400 mM 50% inhibition | Saccharomyces cerevisiae | |
dUTP | - |
Mus musculus | |
dUTP | - |
Ovis aries | |
Fe2+ | - |
Escherichia coli | |
Fe3+ | - |
Escherichia coli | |
guanosine | 1.0 mM, 4% inhibition | Escherichia coli | |
Hg+ | - |
Escherichia coli | |
Hg+ | - |
Mus musculus | |
mercaptoethanol | - |
Escherichia coli | |
Mersalyl acid | - |
Escherichia coli | |
Mersalyl acid | - |
Mus musculus | |
Mersalyl acid | - |
Saccharomyces cerevisiae | |
thymidine | 1.0 mM, 21% inhibition | Escherichia coli | |
uracil arabinoside | 4.0 mM, 48% inhibition | Escherichia coli | |
Urea | above 2 M, reversible inactivation | Escherichia coli | |
uridine | 4.0 mM, 20% inhibition | Escherichia coli | |
Zn2+ | above 10 mM | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
5-Methyldeoxycytidine | - |
Escherichia coli | |
0.0853 | - |
deoxycytidine | - |
Escherichia coli | |
0.087 | - |
5'-fluoro-5'-deoxycytidine | - |
Escherichia coli | |
0.167 | - |
cytidine | - |
Escherichia coli | |
0.26 | - |
cytosine arabinoside | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 1 mM, activity 101% | Escherichia coli | |
Mn2+ | - |
Mus musculus | |
Mn2+ | 10 mM, activity 106% | Escherichia coli | |
Zn2+ | 1 mM, activity 103% | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
gel filtration | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytidine + H2O | Mus musculus | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Escherichia coli | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Saccharomyces cerevisiae | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Ovis aries | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Bacillus cereus | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Mus musculus BALB/c | - |
uridine + NH3 | - |
? | |
cytidine + H2O | Escherichia coli Y-70-272 | - |
uridine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus cereus | - |
- |
- |
Escherichia coli | - |
- |
- |
Escherichia coli Y-70-272 | - |
- |
- |
Mus musculus | - |
mouse | - |
Mus musculus | - |
BALB/c | - |
Mus musculus BALB/c | - |
BALB/c | - |
Ovis aries | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
9.53 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5'-fluoro-5'-deoxycytidine + H2O | - |
Escherichia coli | 5'-fluoro-5'-deoxyuridine + NH3 | - |
? | |
5'-fluoro-5'-deoxycytidine + H2O | - |
Escherichia coli Y-70-272 | 5'-fluoro-5'-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Mus musculus | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Escherichia coli | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5'-methyl-2'-deoxycytidine + H2O | - |
Mus musculus BALB/c | 5'-methyl-2-deoxyuridine + NH3 | - |
? | |
5-methyldeoxycytidine + H2O | - |
Escherichia coli | ? | - |
? | |
cytidine + H2O | - |
Mus musculus | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Escherichia coli | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Saccharomyces cerevisiae | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Ovis aries | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Bacillus cereus | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Mus musculus BALB/c | uridine + NH3 | - |
? | |
cytidine + H2O | - |
Escherichia coli Y-70-272 | uridine + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Mus musculus | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Escherichia coli | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Mus musculus BALB/c | uridine arabinoside + NH3 | - |
? | |
cytosine arabinoside + H2O | - |
Escherichia coli Y-70-272 | uridine arabinoside + NH3 | - |
? | |
deoxycytidine + H2O | - |
Mus musculus | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Escherichia coli | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Mus musculus BALB/c | deoxyuridine + NH3 | - |
? | |
deoxycytidine + H2O | - |
Escherichia coli Y-70-272 | deoxyuridine + NH3 | - |
? | |
additional information | cytosine and cytidine nucleosides are not deaminated by this enzyme | Escherichia coli | ? | - |
? | |
additional information | cytosine and cytidine nucleosides are not deaminated by this enzyme | Escherichia coli Y-70-272 | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 54000 | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
mammalian deminase | - |
Mus musculus |
mammalian deminase | - |
Ovis aries |
yeast cytidine deaminase | - |
Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 7.5 | - |
Escherichia coli |