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Literature summary for 3.5.4.4 extracted from

  • Niu, W.; Shu, Q.; Chen, Z.; Mathews, S.; Di Cera, E.; Frieden, C.
    The role of Zn2+ on the structure and stability of murine adenosine deaminase (2010), J. Phys. Chem. B, 114, 16156-16165.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
holo- and apo-ADA, hanging drop vapor diffusion method, using 20% (w/v) PEG 3350 and 200 mM ammonium sulfate, pH 4.7 for apo-ADA or 25% (w/v) PEG 6000, 20 mM Tris-HCl and pH 8.5 for holo-ADA Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ ADA contains a tightly bound Zn2+ which is required for activity, the stability of the protein is decreased significantly in the absence of Zn2+ Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
1 * 40000 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P03958
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
Mus musculus inosine + NH3
-
?

Subunits

Subunits Comment Organism
monomer 1 * 40000 Mus musculus

Synonyms

Synonyms Comment Organism
ADA
-
Mus musculus