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Literature summary for 3.5.4.38 extracted from

  • Aoufouchi, S.; Faili, A.; Zober, C.; D'Orlando, O.; Weller, S.; Weill, J.C.; Reynaud, C.A.
    Proteasomal degradation restricts the nuclear lifespan of AID (2008), J. Exp. Med., 205, 1357-1368.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
the enzyme displays a different stability depending on the specific cell compartment in which it is located. In a Burkitt’s lymphoma cell line the half-life of activation-induced cytidine deaminase is markedly reduced in the nucleus. This destabilization is accompanied by a polyubiquitination that is revealed in the presence of proteasome inhibitors. The same compartment-specific degradation is observed in activated mouse B cells, and also in a non–B cell line Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the enzyme undergoes constant nucleocytoplasmic shuttling, with a net balance toward export, thus resulting in a main cytoplasmic localization Homo sapiens 5737
-
nucleus the enzyme undergoes constant nucleocytoplasmic shuttling, with a net balance toward export, thus resulting in a main cytoplasmic localization. The enzyme is polyubiquitinated in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens
-
uracil in single-stranded DNA + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination the enzyme is polyubiquitinated in the nucleus. Ubiquitin-mediated nuclear degradation of the enzyme is part of a multilayer control that contributes to the regulation of enzyme function during hypermutation and class switch recombination Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Burkitt lymphoma cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
Homo sapiens uracil in single-stranded DNA + NH3
-
?

Synonyms

Synonyms Comment Organism
activation-induced cytidine deaminase
-
Homo sapiens
AID
-
Homo sapiens