General Stability | Organism |
---|---|
the enzyme displays a different stability depending on the specific cell compartment in which it is located. In a Burkitts lymphoma cell line the half-life of activation-induced cytidine deaminase is markedly reduced in the nucleus. This destabilization is accompanied by a polyubiquitination that is revealed in the presence of proteasome inhibitors. The same compartment-specific degradation is observed in activated mouse B cells, and also in a nonB cell line | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | the enzyme undergoes constant nucleocytoplasmic shuttling, with a net balance toward export, thus resulting in a main cytoplasmic localization | Homo sapiens | 5737 | - |
nucleus | the enzyme undergoes constant nucleocytoplasmic shuttling, with a net balance toward export, thus resulting in a main cytoplasmic localization. The enzyme is polyubiquitinated in the nucleus | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | Homo sapiens | - |
uracil in single-stranded DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZX7 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
ubiquitination | the enzyme is polyubiquitinated in the nucleus. Ubiquitin-mediated nuclear degradation of the enzyme is part of a multilayer control that contributes to the regulation of enzyme function during hypermutation and class switch recombination | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Burkitt lymphoma cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | - |
Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activation-induced cytidine deaminase | - |
Homo sapiens |
AID | - |
Homo sapiens |