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Literature summary for 3.5.4.37 extracted from

  • Weiden, M.D.; Hoshino, S.; Levy, D.N.; Li, Y.; Kumar, R.; Burke, S.A.; Dawson, R.; Hioe, C.E.; Borkowsky, W.; Rom, W.N.; Hoshino, Y.
    Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages (2014), PLoS ONE, 9, e108476.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.37

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 x * 110000, isoform ADAR1S, SDS-PAGE Homo sapiens
150000
-
 x * 150000, isoform ADAR1L, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Homo sapiens
-
 hypoxanthine in double-stranded RNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alveolar macrophage
-
 Homo sapiens
-
bronchoalveolar lavage
-
 Homo sapiens
-
helper T-lymphocyte
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
macrophage
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O
-
 Homo sapiens hypoxanthine in double-stranded RNA + NH3
-
 ?

Subunits

Subunits Comment Organism
? x * 110000, isoform ADAR1S, SDS-PAGE Homo sapiens
? x * 150000, isoform ADAR1L, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
ADAR1
-
 Homo sapiens
ADAR1L isoform Homo sapiens
ADAR1S isoform Homo sapiens
adenosine deaminase acting on RNA-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform ADAR1L is induced by interferon gamma or HIV-1 infection in primary macrophages but not in primary CD4 T cells up

General Information

General Information Comment Organism
malfunction knock-down of ADAR1 increases HIV-1 replication in primary macrophages Homo sapiens
physiological function ADAR1 restricts HIV-1 replication post-transcriptionally in macrophages harboring HIV-1 provirus Homo sapiens