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Literature summary for 3.5.4.37 extracted from

  • Gallo, A.; Galardi, S.
    A-to-I RNA editing and cancer: from pathology to basic science (2008), RNA Biol., 5, 135-139.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Homo sapiens
-
hypoxanthine in double-stranded RNA + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O
-
Homo sapiens hypoxanthine in double-stranded RNA + NH3
-
?

General Information

General Information Comment Organism
physiological function the enzyme is involved in RNA editing in order to generate many different mRNAs from the same gene, increasing the transcriptome and then the proteome. The most frequent RNA editing mechanism in mammals involves the conversion of specific adenosines into inosines by the ADAR family of enzymes. This editing event can change both the sequence and the secondary structure of RNA molecules, with important consequences on both the final proteins and regulatory RNAs. Alteration in RNA editing has been connected to numerous human pathologies and is important in tumor progression. RNA editing on non-coding RNA can affect the secondary (and consequently the tertiary) structure of the RNAs and then modulate and/or prevent RNA-protein and RNA-RNA interactions. RNA editing on non-coding portions of the transcripts could influence splicing, localization, stability and translation efficiency of the transcripts Homo sapiens