Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | Homo sapiens | - |
hypoxanthine in double-stranded RNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine in double-stranded RNA + H2O | - |
Homo sapiens | hypoxanthine in double-stranded RNA + NH3 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme is involved in RNA editing in order to generate many different mRNAs from the same gene, increasing the transcriptome and then the proteome. The most frequent RNA editing mechanism in mammals involves the conversion of specific adenosines into inosines by the ADAR family of enzymes. This editing event can change both the sequence and the secondary structure of RNA molecules, with important consequences on both the final proteins and regulatory RNAs. Alteration in RNA editing has been connected to numerous human pathologies and is important in tumor progression. RNA editing on non-coding RNA can affect the secondary (and consequently the tertiary) structure of the RNAs and then modulate and/or prevent RNA-protein and RNA-RNA interactions. RNA editing on non-coding portions of the transcripts could influence splicing, localization, stability and translation efficiency of the transcripts | Homo sapiens |