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Literature summary for 3.5.4.37 extracted from

  • Herbert, A.; Alfken, J.; Kim, Y.G.; Mian, I.S.; Nishikura, K.; Rich, A.
    A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase (1997), Proc. Natl. Acad. Sci. USA, 94, 8421-8426.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
the Z-DNA binding domain is expressed as a C-terminal glutathione S-transferase fusion in Escherichia coli using a pGEX-5X1 cloning vector Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Homo sapiens editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine hypoxanthine in double-stranded RNA + NH3
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine Homo sapiens hypoxanthine in double-stranded RNA + NH3
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adenine in double-stranded RNA + H2O ADAR1 contains a domain (Zalpha) that binds specifically to the left-handed Z-DNA conformation with high affinity. As formation of Z-DNA in vivo occurs 5' to, or behind, a moving RNA polymerase during transcription, recognition of Z-DNA by DRADA1 provides a plausible mechanism by which DRADA1 can be targeted to a nascent RNA so that editing occurs before splicing Homo sapiens hypoxanthine in double-stranded RNA + NH3
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Synonyms

Synonyms Comment Organism
DRADA1
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 Homo sapiens
dsRNA adenosine deaminase
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 Homo sapiens

General Information

General Information Comment Organism
physiological function editing of RNA changes the read-out of information from DNA by altering the nucleotide sequence of a transcript. One type of RNA editing found in all metazoans uses double-stranded RNA (dsRNA) as a substrate and results in the deamination of adenosine to give inosine, which is translated as guanosine Homo sapiens