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Literature summary for 3.5.4.37 extracted from

  • Desterro, J.M.; Keegan, L.P.; Lafarga, M.; Berciano, M.T.; O'Connell, M.; Carmo-Fonseca, M.
    Dynamic association of RNA-editing enzymes with the nucleolus (2003), J. Cell Sci., 116, 1805-1818.
    View publication on PubMed
Search for more literature for 3.5.4.37

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm full-length and N-terminally truncated forms of ADAR1 are simultaneously expressed in HeLa cells. Because the N-terminus of ADAR1 contains a nuclear export signal, the full-length protein (150000 Da) localizes predominantly in the cytoplasm, whereas the N-terminally truncated forms (110000 Da) are exclusively nuclear and accumulate in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR1 shuttles between the nucleolus, the nucleoplasm and the cytoplasm Homo sapiens 5737
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nucleolus ADAR2 localizes exclusively to the nucleus and accumulates in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR2 shuttles between the nucleolus and the nucleoplasm Homo sapiens 5730
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nucleolus full-length and N-terminally truncated forms of ADAR1 are simultaneously expressed in HeLa cells. Because the N-terminus of ADAR1 contains a nuclear export signal, the full-length protein (150000 Da) localizes predominantly in the cytoplasm, whereas the N-terminally truncated forms (110000 Da) are exclusively nuclear and accumulate in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR1 shuttles between the nucleolus, the nucleoplasm and the cytoplasm Homo sapiens 5730
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine in double-stranded RNA + H2O Homo sapiens ADAR1 is an editing enzyme that deaminates adenosine to inosine in long double stranded RNA duplexes and specific pre-mRNA transcripts hypoxanthine in double-stranded RNA + NH3
-
 ?
adenine in double-stranded RNA + H2O Homo sapiens ADAR2 is an editing enzymes that deaminates adenosine to inosine in long double stranded RNA duplexes and specific pre-mRNA transcripts hypoxanthine in double-stranded RNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P55265
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
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HeLa cell full-length and N-terminally truncated forms of ADAR1 are simultaneously expressed in HeLa cells owing to the usage of alternative starting methionines Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine in double-stranded RNA + H2O
-
 Homo sapiens hypoxanthine in double-stranded RNA + NH3
-
 ?
adenine in double-stranded RNA + H2O ADAR1 is an editing enzyme that deaminates adenosine to inosine in long double stranded RNA duplexes and specific pre-mRNA transcripts Homo sapiens hypoxanthine in double-stranded RNA + NH3
-
 ?
adenine in double-stranded RNA + H2O ADAR2 is an editing enzymes that deaminates adenosine to inosine in long double stranded RNA duplexes and specific pre-mRNA transcripts Homo sapiens hypoxanthine in double-stranded RNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
ADAR1
-
 Homo sapiens
ADAR2
-
 Homo sapiens