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Literature summary for 3.5.4.37 extracted from
- Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design (2003), J. Am. Chem. Soc., 125, 10867-10876.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full-length human ADAR2 is overexpressed in Saccharomyces cerevisiae | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 8-azanebularine | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 8-azaadenine in double-stranded RNA + H2O | 8-aza substitution at adenosine in various RNA substrates accelerates the rate of deamination at these sites by ADAR2 (2.8-17-fold). The magnitude of this effect depends on the RNA structural context of the reacting nucleotide | Homo sapiens | 8-azahypoxanthine in double-stranded RNA + NH3 | - |
? | |
| adenine in double-stranded RNA + H2O | - |
Homo sapiens | hypoxanthine in double-stranded RNA + NH3 | - |
? | |
| additional information | no product is observed with N6-ethyladenosine or 2,6-diaminopurine ribonucleoside in double-stranded RNA | Homo sapiens | ? | - |
? | |
| N6-methyladenine in double-stranded RNA + H2O | slow substrate for ADAR2, 2% of the rate compared to that of adenosine | Homo sapiens | N6-methylhypoxanthine in double-stranded RNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAR2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0012 | - |
adenine in double-stranded RNA | pH 7.5, 30°C | Homo sapiens | |
| 0.0072 | - |
8-azaadenine in double-stranded RNA | pH 7.5, 30°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00004 | - |
8-azanebularine | pH 7.5, 30°C | Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 15 | - |
pH 7.5, 30°C | Homo sapiens | 8-azanebularine | |
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