Literature summary for 3.5.4.37 extracted from

Lehmann, K.A.; Bass, B.L.
Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities (2000), Biochemistry, 39, 12875-12884.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenine in double-stranded RNA + H2O	like ADAR1, ADAR2 has a 5' neighbor preference (A = U > C = G), but, unlike ADAR1, also has a 3' neighbor preference (U = G > C = A). ADAR2 prefers certain trinucleotide sequences (UAU, AAG, UAG, AAU). ADAR1 and ADAR2 have overlapping specificities. Xenopus and human ADAR1 have a highly similar, or identical, deamination specificity	Homo sapiens	hypoxanthine in double-stranded RNA + NH3	-	?

Synonyms

Synonyms	Comment	Organism
ADAR2	-	Homo sapiens

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Release 2023.1 (January 2023)