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Literature summary for 3.5.4.36 extracted from
- Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA (2000), Mol. Cell. Biol., 20, 1846-1854.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine6666 in apolipoprotein B mRNA + H2O | Rattus norvegicus | - |
uracil6666 in apolipoprotein B mRNA + NH3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P38483 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine6666 in apolipoprotein B mRNA + H2O | - |
Rattus norvegicus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
| cytosine6666 in apolipoprotein B mRNA + H2O | the apobec-1 complementation factor (ACF) and apobec-1 comprise the minimal protein requirements for specific and efficient editing of apo-B mRNA in vitro. ACF is also involved in editing in vivo. A model of the enzyme is elaborated in which ACF functions as the RNA-binding subunit that binds to the 11-nucleotide mooring sequence downstream of the editing site and docks apobec-1 to deaminate C6666. The fact that ACF is widely expressed in human tissues that lack apobec-1 and apo-B mRNA suggests that ACF may be involved in other RNA editing or RNA processing events | Rattus norvegicus | uracil6666 in apolipoprotein B mRNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APOBEC-1 | - |
Rattus norvegicus |
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