Literature summary for 3.5.4.36 extracted from

Chester, A.; Somasekaram, A.; Tzimina, M.; Jarmuz, A.; Gisbourne, J.; O'Keefe, R.; Scott, J.; Navaratnam, N.
The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay (2003), EMBO J., 22, 3971-3982.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli or in Sf9 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
cytosine6666 in apolipoprotein B mRNA + H2O	Homo sapiens	APOBEC1, catalytic component of an RNA-editing complex, transports the complementing specificity factor ACF to and from the nucleus as cargo. Expression of APOBEC1 alone edits apoB RNA and generates a substrate for nonsense-mediated decay. The APOBEC1/ACF editing complex protects the edited apoB RNA from nonsense-mediated decay and transports the RNA to the cytoplasm for translation	uracil6666 in apolipoprotein B mRNA + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P41238	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cytosine6666 in apolipoprotein B mRNA + H2O	APOBEC1, catalytic component of an RNA-editing complex, transports the complementing specificity factor ACF to and from the nucleus as cargo. Expression of APOBEC1 alone edits apoB RNA and generates a substrate for nonsense-mediated decay. The APOBEC1/ACF editing complex protects the edited apoB RNA from nonsense-mediated decay and transports the RNA to the cytoplasm for translation	Homo sapiens	uracil6666 in apolipoprotein B mRNA + NH3	-	?

Synonyms

Synonyms	Comment	Organism
APOBEC1	catalytic component of an RNA-editing complex	Homo sapiens

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Release 2023.1 (January 2023)