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Literature summary for 3.5.4.33 extracted from

  • Delannoy, E.; Le Ret, M.; Faivre-Nitschke, E.; Estavillo, G.M.; Bergdoll, M.; Taylor, N.L.; Pogson, B.J.; Small, I.; Imbault, P.; Gualberto, J.M.
    Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation (2009), Plant Cell, 21, 2058-2071.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.33

Cloned(Commentary)

Cloned (Comment) Organism
the C-terminal domain of Arabidopsis TADA (DN-TADA) is expressed in Escherichia coli fused to an N-terminal His tag Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine34 in tRNAArg + H2O Arabidopsis thaliana the chloroplast tRNA editing protein is specifically required for deamination of chloroplast (cp)-tRNAArg(ACG) to cp-tRNAArg(ICG) hypoxanthine34 in tRNAArg + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9S7I0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine34 in tRNAArg + H2O the chloroplast tRNA editing protein is specifically required for deamination of chloroplast (cp)-tRNAArg(ACG) to cp-tRNAArg(ICG) Arabidopsis thaliana hypoxanthine34 in tRNAArg + NH3
-
 ?
adenine34 in tRNAArg + H2O complementation studies show that the C-terminal domain is sufficient for cognate tRNA deamination both in vitro and in planta. TADA is exclusively involved in editing of the prokaryote-type cp-tRNAArg(ACG). No editing of cytosolic tRNAAla(AGC), tRNAVal(AAC), and tRNAThr(AGU). TADA is also not involved in editing of nucleotide A37 of tRNAAla(AGC) Arabidopsis thaliana hypoxanthine34 in tRNAArg + NH3
-
 ?

Synonyms

Synonyms Comment Organism
TadA
-
 Arabidopsis thaliana
tRNA adenosine deaminase arginine
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction disruption of TADA has profound effects on chloroplast translation efficiency, leading to reduced yields of chloroplast-encoded proteins and impaired photosynthetic function Arabidopsis thaliana