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Literature summary for 3.5.4.27 extracted from

  • Shih, C.J.; Lai, M.C.
    Differentially expressed genes after hyper- and hypo-salt stress in the halophilic archaeon Methanohalophilus portucalensis (2010), Can. J. Microbiol., 56, 295-307.
    View publication on PubMed
Search for more literature for 3.5.4.27

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons to other enzymes of the methanogenesis pathway Methanohalophilus portucalensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O Methanohalophilus portucalensis
-
 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O Methanohalophilus portucalensis FDF1
-
 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?

Organism

Organism UniProt Comment Textmining
Methanohalophilus portucalensis A5JHE4 DSM7471, originally isolated from the solar saltern of Figueria da Foz, Portugal
-
Methanohalophilus portucalensis FDF1 A5JHE4 DSM7471, originally isolated from the solar saltern of Figueria da Foz, Portugal
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O
-
 Methanohalophilus portucalensis 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O enzyme residue Lys77 binds to the phosphate moiety of substrate moiety H4MPT Methanohalophilus portucalensis 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O
-
 Methanohalophilus portucalensis FDF1 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?
5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O enzyme residue Lys77 binds to the phosphate moiety of substrate moiety H4MPT Methanohalophilus portucalensis FDF1 5-formyl-5,6,7,8-tetrahydromethanopterin
-
 ?

Synonyms

Synonyms Comment Organism
methenyl-H4MPT cyclohydrolase
-
 Methanohalophilus portucalensis

Expression

Organism Comment Expression
Methanohalophilus portucalensis NaCl downregulates methenyl-H4MPT cyclohydrolase expression down

General Information

General Information Comment Organism
metabolism several of the differentially expressed genes during long-term hyper- or hypo-salt stress are related to the unique energy-acquiring methanogenesis pathway in this organism, including the transmembrane protein MttP, cobalamin biosynthesis protein, methenyl-H4MPT cyclohydrolase and monomethylamine methyltransferase. The methenyl-H4MPT cyclohydrolase participates in the pathway of methyl-group oxidation for transferring methanogenesis substrates into biosynthesis substrates Methanohalophilus portucalensis