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Literature summary for 3.5.4.25 extracted from

  • Asai, S.; Mase, K.; Yoshioka, H.
    A key enzyme for flavin synthesis is required for nitric oxide and reactive oxygen species production in disease resistance (2010), Plant J., 62, 911-924.
    View publication on PubMed
Search for more literature for 3.5.4.25

Protein Variants

Protein Variants Comment Organism
C396S site-directed mutagenesis, Nicotiana benthamiana
E154D site-directed mutagenesis, Nicotiana benthamiana
additional information generation of NbRibA-silenced plants via inoculation with Agrobacterium tumefaciens containing inf1, NbMEK2DD or Bax, or GUS as a control. Silencing NbRibA does not affect the activation of SIPK and defense-related genes, except for NbGST, effects of silencing NbRibA on disease resistance, phenotype Nicotiana benthamiana

Organism

Organism UniProt Comment Textmining
Nicotiana benthamiana D6RUS9 guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; gene NbRibA encoding the bifunctional guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
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Source Tissue

Source Tissue Comment Organism Textmining
leaf
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 Nicotiana benthamiana
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Synonyms

Synonyms Comment Organism
GTPCH II
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 Nicotiana benthamiana
guanosine triphosphate cyclohydrolase II
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 Nicotiana benthamiana
guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
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 Nicotiana benthamiana
NbRibA
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 Nicotiana benthamiana

General Information

General Information Comment Organism
malfunction NbRibA-silenced plants show slightly dwarf phenotypes, levels of endogenous riboflavin and its derivatives FMN and FAD are decreased in NbRibA-silenced Nicotiana benthamiana plants. Silencing of NbRibA compromises not only hypersensitive response cell death, but also the NO and reactive oxygen species production induced by INF1 elicitin and a constitutively active form of NbMEK2, and also induces high susceptibility to oomycete Phytophthora infestans and ascomycete Colletotrichum orbiculare. Compromised radical production and hypersensitive response cell death induced by INF1 in NbRibA-silenced leaves are rescued by adding riboflavin, FMN or FAD Nicotiana benthamiana
metabolism the bifunctional enzyme, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, participates in the biosynthesis of flavin Nicotiana benthamiana