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Literature summary for 3.5.4.2 extracted from

  • Kidder, G.W.; Nolan, L.L.
    Adenine aminohydrolase: occurrence and possible significance in trypanosomid flagellates (1979), Proc. Natl. Acad. Sci. USA, 76, 3670-3672.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
coformycin
-
Crithidia fasciculata
coformycin
-
Leishmania braziliensis
coformycin
-
Leishmania donovani
coformycin
-
Leishmania mexicana
coformycin
-
Leishmania tarentolae
Deoxycoformycin
-
Crithidia fasciculata
Deoxycoformycin
-
Leishmania braziliensis
Deoxycoformycin
-
Leishmania donovani
Deoxycoformycin
-
Leishmania mexicana
Deoxycoformycin
-
Leishmania tarentolae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7 0.8 adenine
-
Leishmania braziliensis
0.8 1 adenine
-
Crithidia fasciculata
1.1 1.4 adenine
-
Leishmania tarentolae
1.7 2 adenine
-
Leishmania mexicana
2 2.2 adenine
-
Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenine + H2O Crithidia fasciculata
-
?
-
?
adenine + H2O Leishmania donovani
-
?
-
?
adenine + H2O Leishmania tarentolae
-
?
-
?
adenine + H2O Leishmania mexicana
-
?
-
?
adenine + H2O Leishmania braziliensis
-
?
-
?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
-
-
Leishmania braziliensis
-
-
-
Leishmania donovani
-
-
-
Leishmania mexicana
-
-
-
Leishmania tarentolae
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.012
-
-
Leishmania braziliensis
0.22
-
-
Leishmania mexicana
0.58
-
-
Leishmania tarentolae
0.64
-
-
Leishmania donovani
0.71
-
-
Crithidia fasciculata

Storage Stability

Storage Stability Organism
4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses Crithidia fasciculata
4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses Leishmania tarentolae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine + H2O
-
Crithidia fasciculata hypoxanthine + NH3
-
?
adenine + H2O
-
Leishmania donovani hypoxanthine + NH3
-
?
adenine + H2O
-
Leishmania tarentolae hypoxanthine + NH3
-
?
adenine + H2O
-
Leishmania mexicana hypoxanthine + NH3
-
?
adenine + H2O
-
Leishmania braziliensis hypoxanthine + NH3
-
?
adenine + H2O
-
Crithidia fasciculata ?
-
?
adenine + H2O
-
Leishmania donovani ?
-
?
adenine + H2O
-
Leishmania tarentolae ?
-
?
adenine + H2O
-
Leishmania mexicana ?
-
?
adenine + H2O
-
Leishmania braziliensis ?
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
95% loss of activity after 1 min Leishmania donovani
50
-
95% loss of activity after 1 min Leishmania tarentolae
50
-
95% loss of activity after 1 min Leishmania mexicana
50
-
95% loss of activity after 1 min Leishmania braziliensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Crithidia fasciculata
8
-
-
Leishmania donovani
8
-
-
Leishmania tarentolae
8
-
-
Leishmania mexicana
8
-
-
Leishmania braziliensis