Inhibitors | Comment | Organism | Structure |
---|---|---|---|
coformycin | - |
Crithidia fasciculata | |
coformycin | - |
Leishmania braziliensis | |
coformycin | - |
Leishmania donovani | |
coformycin | - |
Leishmania mexicana | |
coformycin | - |
Leishmania tarentolae | |
Deoxycoformycin | - |
Crithidia fasciculata | |
Deoxycoformycin | - |
Leishmania braziliensis | |
Deoxycoformycin | - |
Leishmania donovani | |
Deoxycoformycin | - |
Leishmania mexicana | |
Deoxycoformycin | - |
Leishmania tarentolae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | 0.8 | adenine | - |
Leishmania braziliensis | |
0.8 | 1 | adenine | - |
Crithidia fasciculata | |
1.1 | 1.4 | adenine | - |
Leishmania tarentolae | |
1.7 | 2 | adenine | - |
Leishmania mexicana | |
2 | 2.2 | adenine | - |
Leishmania donovani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine + H2O | Crithidia fasciculata | - |
? | - |
? | |
adenine + H2O | Leishmania donovani | - |
? | - |
? | |
adenine + H2O | Leishmania tarentolae | - |
? | - |
? | |
adenine + H2O | Leishmania mexicana | - |
? | - |
? | |
adenine + H2O | Leishmania braziliensis | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Leishmania braziliensis | - |
- |
- |
Leishmania donovani | - |
- |
- |
Leishmania mexicana | - |
- |
- |
Leishmania tarentolae | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.012 | - |
- |
Leishmania braziliensis |
0.22 | - |
- |
Leishmania mexicana |
0.58 | - |
- |
Leishmania tarentolae |
0.64 | - |
- |
Leishmania donovani |
0.71 | - |
- |
Crithidia fasciculata |
Storage Stability | Organism |
---|---|
4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses | Crithidia fasciculata |
4°C, 10 mM phoshate buffer, pH7.5, 20 mM 2-mercaptoethanol, 1-2 weeks, minimal losses | Leishmania tarentolae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine + H2O | - |
Crithidia fasciculata | hypoxanthine + NH3 | - |
? | |
adenine + H2O | - |
Leishmania donovani | hypoxanthine + NH3 | - |
? | |
adenine + H2O | - |
Leishmania tarentolae | hypoxanthine + NH3 | - |
? | |
adenine + H2O | - |
Leishmania mexicana | hypoxanthine + NH3 | - |
? | |
adenine + H2O | - |
Leishmania braziliensis | hypoxanthine + NH3 | - |
? | |
adenine + H2O | - |
Crithidia fasciculata | ? | - |
? | |
adenine + H2O | - |
Leishmania donovani | ? | - |
? | |
adenine + H2O | - |
Leishmania tarentolae | ? | - |
? | |
adenine + H2O | - |
Leishmania mexicana | ? | - |
? | |
adenine + H2O | - |
Leishmania braziliensis | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
95% loss of activity after 1 min | Leishmania donovani |
50 | - |
95% loss of activity after 1 min | Leishmania tarentolae |
50 | - |
95% loss of activity after 1 min | Leishmania mexicana |
50 | - |
95% loss of activity after 1 min | Leishmania braziliensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Crithidia fasciculata |
8 | - |
- |
Leishmania donovani |
8 | - |
- |
Leishmania tarentolae |
8 | - |
- |
Leishmania mexicana |
8 | - |
- |
Leishmania braziliensis |